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McKinzie Frederick

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Amyloid-β oligomers trigger sex-dependent inhibition of GIRK channel activity in hippocampal neurons in mice

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By Karina Chaudhari, Haichang Luo, Wei Wong Verified, Carolina Aguado, Benjamin M Gansemer, Rafael Luján, Stanley A Thayer, Kevin Wickman, McKinzie Frederick
| Science Magazine Verified
Editor’s summary Early stages of Alzheimer’s disease (AD) are associated with amyloid-β (Aβ) deposition and enhanced neuronal excitability, and loss of inhibitory G protein–gated K+ (GIRK) channel activity has been implicated in rodent AD models. Luo et al. identified a sex-dependent mechanism by which Aβ oligomers suppressed GIRK channel activity in hippocampal neurons.
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