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Mecca B.A.R Islam on Muck Rack

Mecca B.A.R Islam

As seen in: BioRxiv
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Articles

antiCD49d Ab treatment ameliorates age-associated inflammatory response and mitigates CD8 T cell cytotoxicity after traumatic brain injury

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By Zhangying Jennie Chen, Kacie P Ford, Mecca B.A.R Islam, Hanxiao Wan
| BioRxiv
Abstract Patients aged 65 years and older account for an increasing proportion of patients with traumatic brain injury (TBI). Older TBI patients experience increased morbidity and mortality compared to their younger counterparts. Our prior data demonstrated that by blocking α4 integrin, anti-CD49d antibody (aCD49d Ab) abrogates CD8+ T-cell infiltration into the injured brain, improves survival, and attenuates neurocognitive deficits.
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