Isaac S. Kohane on Muck Rack

Isaac S. Kohane

Boston
As seen in: LinkedIn, Nature, Wiley Online Library, PLOS ONE, Archives of Disease in Childhood, BMJ Quality & Safety, Flipboard, JAMA (The Journal of the American Medical Association), JAMA: Journal of the American Medical Association, The Boston Globe and
Computer science + Biomedicine = Medicine as a Knowledge Processing Discipline @harvardMED @HarvardDBMI Prof/Dept Chair zaklab.org MD/PhD @NEJM AI EIC
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Articles

Phenotypic prediction of missense variants via deep contrastive learning

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By Jun Wen, Sihang Zeng, Clara-Lea Bonzel, Shilpa Nadimpalli Kobren, Jiangchuan Du, Yi Chai, Hao Wang, Meng Zhu, Siwei Chen, Fangwei Leng, Harrison Zhang, Katherine P Liao, Kelly Kasulis Cho, Isaac S. Kohane, Marinka Zitnik, Alexandre C. Pereira, Jun Liu, Tianxi Cai
| Nature
Abstract Missense variants (MVs) influence clinical phenotypes, but our understanding of their phenotypic consequences remains constrained. Existing computational approaches to interpret MVs predominantly assess their pathogenicity, without considering phenotypic heterogeneity.
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Scaling medical AI across clinical contexts

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By Michelle Li , Ben Y Reis, Adam Rodman, Tianxi Cai, Noa Dagan, Ran D Balicer, Joseph Loscalzo, Isaac S. Kohane, Marinka Zitnik
| Nature
Abstract Medical artificial intelligence (AI) tools, including clinical language models, vision–language models and multimodal health record models, are used to summarize clinical notes, answer questions and support decisions. Their adaptation to new populations, specialties or care settings often relies on fine-tuning, prompting or retrieval from external knowledge bases.
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Your AI doctor may be working for someone else - The Boston Globe

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By Isaac S. Kohane
| The Boston Globe
Dr. Isaac Kohane is the founding chair of the department of biomedical informatics at Harvard Medical School and coauthor of “The AI Revolution in Medicine: GPT-4 and Beyond.” Nearly half of Americans now turn to AI chatbots for health advice — everything from lifestyle tweaks to second opinions on cancer treatment.
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