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Intravenous methylphenidate for acute traumatic disorders of consciousness: A phase 1 dose-finding and target engagement study
The authors have declared no competing interest. NCT03814356 I confirm all relevant ethical guidelines have been followed, and any necessary IRB and/or ethics committee approvals have been obtained. Yes The details of the IRB/oversight body that provided approval or exemption for the research described are given below: This study was approved by the Mass General Brigham Institutional Review Board.
Disorders of Consciousness Associated With COVID-19
Abstract Background and Objectives In patients with severe coronavirus disease 2019 (COVID-19), disorders of consciousness (DoC) have emerged as a serious complication. The prognosis and pathophysiology of COVID-DoC remain unclear, complicating decisions about continuing life-sustaining treatment. We describe the natural history of COVID-DoC and investigate its associated brain connectivity profile.
Disorders of Consciousness Associated With COVID-19: A Prospective, Multimodal Study of Recovery and Brain Connectivity
December 03, 2021Research ArticleOpen Access First published December 3, 2021, DOI: https://doi.org/10.1212/WNL.0000000000013067 Abstract Background and Objectives: In patients with severe coronavirus disease 2019 (COVID-19), disorders of consciousness (COVID-DoC) have emerged as a serious complication. The prognosis and pathophysiology of COVID-DoC remain unclear, complicating decisions about continuing life-sustaining treatment.
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