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Megan-Lee Burger

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Diagnostic accuracy of CRP and myeloperoxidase as a 2-marker biosignature for the diagnosis of symptomatic TB

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By Bih H. Chendi, Kim Stanley, Maynard Meiring, Tejas Shah, Stephanus Malherbe, Martin Kidd, Harriet Mayanja-Kizza, Jayne S. Sutherland, Gerhard Walzl, Adrian Woolfson, Novel Chegou, Lesego Rantho, Megan-Lee Burger, Marika Flinn, Belinda Kriel, Candice I. Synders, Shalena Naidoo, Simona John von Freyend
| Nature Verified
Abstract Non-sputum-based tests are urgently needed for rapid tuberculosis (TB) diagnosis. While the World Health Organization (WHO) recommends C-reactive protein (CRP) in serum as a TB screening tool for people living with HIV, it falls short of meeting the minimum target product profile (TPP) criteria for a triage test. We hypothesized that combining CRP with Myeloperoxidase (MPO) as a two-protein signature, would diagnose TB with improved accuracy.
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