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Megana Thamilselvan on Muck Rack

Megana Thamilselvan

As seen in: Wiley Online Library, BioRxiv, The Gateway
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Articles

GenoStaR: An R Package for Genotype to Star Allele Conversion for Major Cytochrome P450 Family of Genes

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By Alex Coulter, Megana Thamilselvan, James Kennedy, Clement C Zai
| Wiley Online Library Verified
In pharmacogenomics, converting genotypes to haplotypes enables predictions of drug metabolism and dosing recommendations.
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Single molecule long-read real-time amplicon-based sequencing of CYP2D6: a proof-of-concept with hybrid haplotypes

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By Megana Thamilselvan, Jerome C. Foo, Rachael Dong, Jacqueline DeJarnette
| BioRxiv
Abstract CYP2D6 is a widely expressed human xenobiotic metabolizing enzyme, best known for its role in the hepatic phase I cytochrome P450 enzyme system, where it metabolizes ~20% of medications. It is also expressed in other organs including the brain, where its potential role in physiology and mental health traits and disorders is under further investigation.
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Haplotype phasing of CYP2D6: an allelic ratio method using Agena MassARRAY data

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By Megana Thamilselvan, Katherine J. Aitchison
| BioRxiv
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