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Meherun Binta Alam on Muck Rack

Meherun Binta Alam

As seen in: BioRxiv
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Articles

High-Throughput Screening Reveals Potential Inhibitors Targeting Trimethoprim-Resistant DfrA1 Protein in Klebsiella pneumoniae and Escherichia coli

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By Soharth Hasnat, Soaibur Rahman, Meherun Binta Alam, Farha Mohi Suin
| BioRxiv
Abstract The DfrA1 protein provides trimethoprim resistance in bacteria, especially Klebsiella pneumoniae and Escherichia coli, by modifying dihydrofolate reductase, which reduces the binding efficacy of the antibiotic. Thus, this study aimed to identify inhibitors of the trimethoprim-resistant DfrA1 protein through high-throughput computational screening of 3,601 newly synthesized chemical compounds sourced from the ChemDiv database.
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