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Mehtap Bayin

As seen in: Color Research & Application
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Articles

A SARS‐CoV‐2 Spike Binding DNA Aptamer that Inhibits Pseudovirus Infection by an RBD‐Independent Mechanism**

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By Anton Schmitz, Anna Weber, Mehtap Bayin, Stefan Breuers
| Color Research & Application Verified
Abstract The receptor binding domain (RBD) of the spike glycoprotein of the coronavirus SARS‐CoV‐2 (CoV2‐S) binds to the human angiotensin‐converting enzyme 2 (ACE2) representing the initial contact point for leveraging the infection cascade. We used an automated selection process and identified an aptamer that specifically interacts with CoV2‐S. The aptamer does not bind to the RBD of CoV2‐S and does not block the interaction of CoV2‐S with ACE2.
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A SARS‐CoV‐2 spike binding DNA aptamer that inhibits pseudovirus infection by an RBD independent mechanism

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By Günter Mayer, Anton Schmitz, Anna Weber, Mehtap Bayin
| pericles.pericles-prod.literatumonline.com
Research Article Günter Mayer Corresponding Author gmayer@uni-bonn.de University of Bonn, LIMES, Gerhard-Domagk-Szt. 1, 53121 Bonn, GERMANY Search for more papers by this author PDF ShareShare Abstract The receptor binding domain (RBD) of the spike glycoprotein of the coronavirus SARS‐CoV‐2 (CoV2‐S) binds to the human angiotensin converting enzyme 2 (ACE2) representing the initial contact point for leveraging the infection cascade.
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