Mehul Vora

eLife Assessment Modulation of BMP signaling affects body size in the nematode Caenorhabditis elegans, and this paper examines the effects on C. elegans body size brought about by the modulation of BMP signaling. The study provides valuable analyses of ChIP-seq and RNA-seq data to understand the function of SMA-3 (Smad) and SMA-9 (Schnurri) in this model.

Abstract Smads and their transcription factor partners mediate the transcriptional responses of target cells to secreted ligands of the Transforming Growth Factor-β (TGF-β) family, including those of the conserved bone morphogenetic protein (BMP) family, yet only a small number of direct target genes have been well characterized. In C. elegans, the BMP2/4 ortholog DBL-1 regulates multiple biological functions, including body size, via a canonical receptor-Smad signaling cascade.

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