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Regulation of the NRF2 transcription factor by andrographolide and organic extracts from plant endophytes

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By Mei Ying Ng, Jia Yu Leung, Boon Kim Boh, Ee Chien Lim
| PLOS
The transcription factor NF-E2 Related Factor-2 (NRF2) is an important drug target. Activation of NRF2 has chemopreventive effects in cancer and exerts beneficial effects in a number of diseases, including neurodegenerative diseases, inflammatory diseases, hepatosteatosis, obesity and insulin resistance. Hence, there have been great efforts to discover and characterize novel NRF2 activators. One reported NRF2 activator is the labdane diterpenoid andrographolide.
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