Meike Hedwig Keuters on Muck Rack

Meike Hedwig Keuters

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Sustained meningeal lymphatic vessel atrophy or expansion does not alter Alzheimer’s disease-related amyloid pathology - Nature Cardiovascular Research

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By Salli Antila, Zhilin Li, Valeriia Sitnikova, Henna Jäntti, Lenka Dvorakova, Abhishek Singh, Jari E. Koistinaho, Sinem Karaman, Tarja Malm, Heikki Tanila, Meike Hedwig Keuters, Lauri Eklund
| Nature Verified
Abstract Discovery of meningeal lymphatic vessels (LVs) in the dura mater, also known as dural LVs (dLVs) that depend on vascular endothelial growth factor C expression, has raised interest in their possible involvement in Alzheimer’s disease (AD). Here we find that in the APdE9 and 5xFAD mouse models of AD, dural amyloid-β (Aβ) is confined to blood vessels and dLV morphology or function is not altered.
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