Meiying Zhang
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Rechallenge After Immune Checkpoint Inhibitors Myocarditis: Evidence and a Practical Framework: JACC Cardio-Oncology Primer
JACC Journals › JACC: CardioOncology › Archives › Just Accepted Primers in Cardio-Oncology Share on : JACC: CardioOncology Just Accepted Immune checkpoint inhibitors (ICIs) have transformed outcomes across multiple malignancies, but ICI myocarditis remains one of the most feared immune-related adverse events because it is uncommon, not predictable, and potentially fatal.1-3 As such, current guidance has favored permanent discontinuation, especially after symptomatic or severe myocarditis.4,5...
Defect of MLH1 expression sensitized esophageal squamous cell carcinoma cells to Polθ inhibitor
ABSTRACT Background A large scale detection of MLH1 methylation is lacking in esophageal cancer. MLH1 is a well-known mismatch repair gene. The mechanism of MLH1 in DNA double strand break (DSB) repair remains unclear. Methods Esophageal cancer cell lines and 1018 cases of primary cancer samples were employed. Methylation specific PCR, Western Blot, and CRISPR/Cas9 knockout technique were utilized. Results Methylation of MLH1 was detected in 3.93%.
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