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Articles by Melanie Balbach
Bovine serum albumin‐induced calcium influx triggers soluble adenylyl cyclase activation and cyclic AMP signalling pathways in mouse sperm capacitation
References , , , , , , & (2019). ADCY10 frameshift variant leading to severe recessive asthenozoospermia and segregating with absorptive hypercalciuria. Human Reproduction, 34(6), 1155–1164. , , , & (1996). Activation of mouse sperm T-type Ca2+ channels by adhesion to the egg zona pellucida. Proceedings of the National Academy of Sciences, USA, 93(23), 13004–13009. , , , , , , , , , , , , , , & (2021). Soluble adenylyl cyclase inhibition prevents human sperm functions essential for fertilization.
Cyclic AMP Rescue of Motility in Sperm Devoid of Soluble Adenylyl Cyclase
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Deciphering rapid cell signaling and control of cell motility by reverse opto-chemical engineering
Abstract Cells transform complex environmental stimuli into physiological responses. For time-varying stimuli or motile cells, the perception of the environment depends on the temporal stimulus pattern and cell motion, respectively. Here we report a concept, reverse optochemical engineering (ROCE), that uses temporal light patterns and photo-triggers to expose cells to virtual sensory landscapes while recording in real time their physiological responses and motor behavior.
A New Male Contraceptive Pill Is In Development, And The Internet Reactions Are Wild
Dispatchist News from around the globe in real time Client login News Sources Countries People Categories Organizations A new on-demand, non-hormonal male contraceptive pill is in progress.
Male contraceptive shows promise in mice, study suggests
The study’s co-senior authors Dr Jochen Buck and Dr Lonny Levin, who are professors of pharmacology at Weill Cornell Medicine, say the discovery could be a “game-changer” for contraception. The study found that mice given the drug that inactivates an enzyme called soluble adenylyl cyclase (sAC) produced sperm that could not propel themselves forward. This suggests the inhibitors can reduce the movement of mouse and human sperm, a key indicator of sperm function, the scientists say.
Using an Extracellular Flux Analyzer to Measure Changes in Glycolysis and Oxidative Phosphorylation during Mouse Sperm Capacitation
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