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Melih Arda Ozsoy on Muck Rack

Melih Arda Ozsoy

As seen in: Nature
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Articles

A novel CAF population coordinates hyper-suppressive regulatory T cell recruitment and localization in lung cancer

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By Olivia R Ringham, Monica Rivera, Lucas F. Loffredo, Yinuo Jin, Noah Chen, Kenia de los Santos-Alexis, Elham Azizi, Anjali Saqi, Matthew Buechler, Nicholas Arpaia, Melih Arda Ozsoy, Christina M. Healy, Carla P. Concepcion-Crisol
| Nature Verified
Abstract Across many solid tumor types, cancer-associated fibroblasts (CAFs) are abundant and heterogeneous, with distinct subpopulations exerting immunomodulatory functions. Here we identify a novel population of immunomodulatory CAFs (imCAFs) in primary lung adenocarcinoma and pulmonary metastases, characterized by cell adhesion molecule L1-like (CHL1) expression and enriched in immune regulation and chemokine signaling programs.
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