Melinda Halasz on Muck Rack

Melinda Halasz

Dublin
As seen in: Nature, MDPI, Genome Medicine
Physician-scientist fighting against childhood cancer.
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Articles

MYCN inhibits TrkC-mediated differentiation in neuroblastoma cells via disruption of the PKA signalling pathway

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By Stephanie Maher, Andrew Roe, Kieran Wynne, Vadim Zhernovkov, Melinda Halasz
| Nature
Abstract Neuroblastoma is a rare childhood cancer in which high-risk disease, frequently driven by MYCN amplification, has poor survival. Trk-receptor expression correlates with prognosis: TrkA is observed in low-risk cases while TrkB is often expressed in high-risk MYCN-amplified neuroblastoma. However, TrkC’s role in neuroblastoma genesis remains unclear. This study investigates the interplay between TrkC signalling and MYCN status.
Open in Who Shared Issue with article?

Epigenetic Dysregulation in MYCN-Amplified Neuroblastoma

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By Melinda Halasz, Shin Mei, Soraya Epp, Shin Mei Chuah
| MDPI
All articles published by MDPI are made immediately available worldwide under an open access license. No special permission is required to reuse all or part of the article published by MDPI, including figures and tables. For articles published under an open access Creative Common CC BY license, any part of the article may be reused without permission provided that the original article is clearly cited. For more information, please refer to https://www.mdpi.com/openaccess.
Open in Who Shared View Duplicates (57) Issue with article?

Control of cell state transitions - Nature

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By Melinda Halasz, Stephanie Maher, Walter Kolch, Nora Rauch
| Nature
Abstract Understanding cell state transitions and purposefully controlling them is a longstanding challenge in biology. Here we present cell state transition assessment and regulation (cSTAR), an approach for mapping cell states, modelling transitions between them and predicting targeted interventions to convert cell fate decisions.
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