Mellad Khoshnood

Introduction Down syndrome (DS) is a leading cause of intellectual and developmental disability worldwide and occurs in ~1 in 700 live births in the United States.1 A rare but increasingly diagnosed condition in this population is Down Syndrome Regression Disorder (DSRD) which is an acute or subacute loss of previously acquired developmental skills in the areas of language, communication, cognition, executive function, behavioral, and adaptive skills.2-6 Individuals with DSRD frequently...

Introduction Down syndrome (DS), a genetic condition most often caused by trisomy of chromosome 21, and is one of the most common genetic disorders, occurring in approximately 1 in every 700 live births in the United States.1, 2 Individuals with DS have well-phenotyped neurologic and psychiatric disease, although acute and subacute neurocognitive regression of unclear etiology in individuals considered too young to develop Alzheimer's disease (AD) and too old to develop autism spectrum...

CONFLICT OF INTEREST STATEMENT The authors report no conflicts of interest. REFERENCES , , , , , , , , , , , , , , & (2019). Trisomy 21 dysregulates T cell lineages toward an autoimmunity-prone state associated with interferon hyperactivity. Proceedings of the National Academy of Sciences of the United States of America, 116(48), 24231–24241. https://doi.org/10.1073/pnas.1908129116 , & (2020).