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Mendee A. Geist on Muck Rack

Mendee A. Geist

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Articles

A novel mouse model for developmental and epileptic encephalopathy by Purkinje cell-specific deletion of Scn1b

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By F. Isaac Guillen, Mendee A. Geist, Shao-Ying Cheng, Arwen M. Harris
| BioRxiv
Abstract Loss of function variants of SCN1B are associated with a range of developmental and epileptic encephalopathies (DEEs), including Dravet syndrome. These DEEs feature a wide range of severe neurological disabilities, including changes to social, motor, mood, sleep, and cognitive function which are notoriously difficult to treat, and high rates of early mortality.
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