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Meng-Fu Bryan Tsou on Muck Rack

Meng-Fu Bryan Tsou

As seen in: Nature
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Articles

Adaptable centriole biogenesis via the intrinsically disordered protein ALMS1

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By Kanako Ozaki, Ting-Jui Ben Chang, Wen-Qing Yang, Wann-Neng Jane, Won-Jing Wang, Tim Stearns, Jens Lüders, T. Tony Yang, Meng-Fu Bryan Tsou, Avital Shulman, Denisse Izquierdo
| Nature Verified
Abstract Centriole biogenesis is viewed as a template-free physical transformation where a cartwheel scaffold emerges to guide centriole growth and subsequently disassembles; however, the mechanism underlying cartwheel dynamics remains obscure. Here, we identify the intrinsically disordered protein (IDP) ALMS1 as an external cofactor that causes a seed for cartwheel formation without itself incorporating into the seed structure.
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By Kunihiro Uryu, Meng-Fu Bryan Tsou, Gregory Mazo, Nadine Soplop, Won-Jing Wang
| secure.jbs.elsevierhealth.com
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By MinHee Kim, Brian O’Rourke, Rajesh Kumar Soni, Prasad V. Jallepalli, Ronald C. Hendrickson, Meng-Fu Bryan Tsou
| secure.jbs.elsevierhealth.com
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