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Meng Nian on Muck Rack

Meng Nian

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Articles

Enhancing pulp regeneration through metabolic reprogramming of mature dental pulp stem cells mediated by GLUT1/HK2 mRNA delivery

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By Yuhan Liu, Zhili Li, Lulu Wang, Peiyi Li, Dezhong Zhou, Lina Niu, Yujiang Chen, Tiankai Di, Meng Nian
| Nature Verified
Abstract The age-related decline in the pro-angiogenic capacity of mature dental pulp stem cells (DPSCs) severely limits pulp regeneration. We identify impaired glycolytic metabolism, driven by reduced glucose transporter type 1 (GLUT1) and hexokinase 2 (HK2) expression, as the key mechanism, as its inhibition diminished endothelial tube formation.
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