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Mengjia Qian

As seen in: Nature, The BMJ
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Articles

Single-cell identifies and validates human circulating Treg subtype/state Treg fci in non-small cell lung cancer

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By Xuanqi Liu, Yifei Liu, Jianming Weng, Hao Dai, Fangming Liu, Lingyan Wang, Mengjia Qian, Bijun Zhu, Shuyao Wu, Youqiong Ye, Mingjie Wang, Yunfeng Cheng, Tianxiang Chen, Duojiao Wu, Yuanlin Song, Xiangdong Wang, Wanxin Duan, Muhan Yuan, Shaojun Hong
| Nature Verified
Abstract Regulatory T cells (Treg) play immunosuppressive roles in lung cancer and are key biomarkers in cancer immunology. Using scRNA-seq and stereo-seq, we aimed to identify a novel circulating Treg subtype in non-small cell lung cancer (NSCLC). We developed a regional overlap-expression rate (rOER) system with cell identity marker gene panels (ciMGPs) to quantify T cell subtype specificity across pre/post-operative blood, 31 diseases, and in 17 organs.
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Immunosuppressive microenvironment of liver restrains chemotherapeutic efficacy in triple-negative breast cancer

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By Wen Sun, Xiaowei Sun, Mingduo Liu, Mengjia Qian
| The BMJ Verified
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