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Downregulation of USP9X in the DG Region of the Hippocampus Leads to AD‐Like Cognitive Dysfunction in Mice
1 Introduction Alzheimer's disease (AD), is the most prevalent neurodegenerative disease worldwide, primarily characterized by impaired cognitive decline, memory impairment, and progressive neuronal loss. Currently, AD affects approximately 55 million people globally; and with the rapid aging of populations, this number is projected to rise significantly, reaching 139 million by 2050 [1]. The pathological hallmarks of AD include three major structural alterations.
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