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Cellular stress triggers degradation and global redistribution of RNAPII
Abstract INTRODUCTION RESULTS DISCUSSION MATERIALS AND METHODS Acknowledgments Supplementary Materials REFERENCES Information & Authors Metrics & Citations View Options References Figures Tables Media Share Abstract Transcription is essential for cellular stress response. However, how RNAPII respond to and are regulated during stress are poorly understood. We show that RNAPII is degraded during many types of cellular stresses.
CDC6/THBS1 accelerates pancreatic cancer progression via AKT-mediated glycolytic reprogramming
Abstract Pancreatic cancer remains one of the most aggressive malignancies, characterized by early metastatic spread and intrinsic resistance to chemotherapy, which ultimately results in poor treatment outcomes. While the Cell Division Cycle 6 (CDC6) protein has been extensively characterized across multiple cancer types, its functional role in the pathogenesis of pancreatic cancer remains poorly understood.
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