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A multicenter prospective cohort study developing and validating a SIRI-based machine learning model and simplified risk score for predicting postherpetic neuralgia
Abstract Background: Postherpetic neuralgia (PHN) is the most common and severe complication of herpes zoster (HZ), and early identification of high-risk patients remains a major clinical challenge. The systemic inflammatory response index (SIRI) is a novel inflammatory marker that has demonstrated prognostic value in multiple diseases, but its association with the risk of PHN development has not been reported to date.
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