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Menusha Arumugam on Muck Rack

Menusha Arumugam

As seen in: BioRxiv
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Articles

Hyperlipidemia drives tumor growth in a mouse model of obesity-accelerated breast cancer growth.

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By Renan Vieira, Menusha Arumugam, Meghan C Curtin, Sawyer R Sanchez
| BioRxiv
Abstract Obesity is an established risk factor for breast cancer (BC), yet the specific mechanisms driving this association remain unclear. Dysregulated lipid metabolism has emerged as a key factor in cancer cell biology. While obesity is often accompanied by hyperlipidemia, the isolated impact of elevated lipid levels on BC growth has not been experimentally tested.
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Zinc Alpha-2-Glycoprotein (ZAG/AZGP1) secreted by triple-negative breast cancer promotes tumor microenvironment fibrosis.

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By Surbhi Verma, Menusha Arumugam, Stephanie Dudics Giagnocavo, Meghan C Curtin
| BioRxiv
Abstract Obesity is a predisposition factor for breast cancer, suggesting a localized, reciprocal interaction between breast cancer cells and the surrounding mammary white adipose tissue. To investigate how breast cancer cells alter the composition and function of adipose tissue, we screened the secretomes of ten human breast cancer cell lines for the ability to modulate the differentiation of adipocyte stem and progenitor cells (ASPC).
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Nf1 Deficiency Increases Mammary Collagen Deposition and Restricts Adipocyte Differentiation Before Tumor Formation

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By Elizabeth A Tovar, Curt J Essenburg, Patrick S. Dischinger, Menusha Arumugam
| BioRxiv
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