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Mera K. Tilley on Muck Rack

Mera K. Tilley

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Safety, tolerability, pharmacokinetics, and pharmacodynamics of the oral allosteric TYK2 inhibitor ESK‐001 using a randomized, double‐blind, placebo‐controlled study design - Ucpinar - 2024 - Clinical and Translational Science - Wiley Online Library

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By Joshua Hoffman, Sibel Ucpinar, Joyce K. Kwan, Mera K. Tilley
| Wiley Online Library Verified
WHAT IS THE CURRENT KNOWLEDGE ON THE TOPIC? The allosteric inhibition of tyrosine kinase 2 (TYK2) shows great promise in the treatment of immune-mediated diseases, including plaque psoriasis. WHAT QUESTION DID THIS STUDY ADDRESS? This phase I study in healthy adults assessed the safety, tolerability, PK, and PD of the oral allosteric TYK2 inhibitor ESK-001. WHAT DOES THIS STUDY ADD TO OUR KNOWLEDGE?
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