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Mercedes Barrero on Muck Rack

Mercedes Barrero

As seen in: Science Magazine, BioRxiv, eLife
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Articles

Chromatin activity of IκBα mediates the exit from naïve pluripotency

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By Luis G Palma, Daniel Alvarez-Villanueva, Maria Maqueda, Mercedes Barrero
| eLife
eLife Assessment This important study describes a non-canonical role for IκBα in regulating mouse embryonic stem cell pluripotency and differentiation, independent of the classical NF-κB pathway. The conclusions are convincingly supported through orthogonal approaches and separation of function mutants. The findings add new insight into pluripotency regulation in mouse cells.
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Chromatin enhancer activity of IκBα mediates the exit from naïve pluripotency

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By Daniel Alvarez-Villanueva, Maria Maqueda, Mercedes Barrero, Luis G Palma
| BioRxiv
Abstract Maintenance of pluripotency is a multifactorial process in which NF-κB is a negative regulator. Our previous work identified a chromatin role for IκBα, the master regulator of NF-κB signaling, that is critical for the proper regulation of various tissue stem cells. Here, we found that IκBα accumulates specifically in the chromatin fraction of pluripotent embryonic stem cells.
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Epitranscriptomic m5C methylation of SARS-CoV-2 RNA regulates viral replication and the virulence of progeny viruses in the new infection

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By Joon Pyung Seo, Yan Feng, Mercedes Barrero, Hongyun Wang
| Science Magazine Verified
Abstract While the significance of N6-methyladenosine (m6A) in viral regulation has been extensively studied, the functions of 5-methylcytosine (m5C) modification in viral biology remain largely unexplored. In this study, we demonstrate that m5C is more abundant than m6A in severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and provide a comprehensive profile of the m5C landscape of SARS-CoV-2 RNA.
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