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Articles

Speech-based digital endpoints track ALS progression and align with standard clinical outcomes: evidence from the VRG50635 trial

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By Michael Neumann, Hardik Kothare, Meredith Bartlett, Diego Cadavid, Ines Hoffmann, Shane Raines, Philip Van Damme, Pentti J. Tienari, Eino Solje, Manu Jokela, Angela Genge, Colleen O’Connell, Leonard van den Berg, Vikram Ramanarayanan, Oliver Roesler, Christiane Suendermann-Oeft, Abhishek Hosamath, Lakshmi Arbatti, David Pautler, David Suendermann-Oeft, Robert H. Scannevin, Anil Tarachandani, Tara Haley, Ruben P. A. van Eijk
| Nature Verified
Abstract We report on the utility of speech-based digital endpoints measured during a Phase 1b study of VRG50635 in Amyotrophic Lateral Sclerosis (ALS). Fifty-four participants with ALS were enrolled and participated in an 8-week pretreatment run-in, followed by three 8-week dosing periods and an 8-week follow-up. They completed a speech assessment every two weeks in the clinic or at home.
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