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Articles

Transposon Mutagenesis Screen of Klebsiella pneumoniae Identifies Multiple Genes Important for Resisting Antimicrobial Activities of Neutrophils in Mice

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By Michelle K. Paczosa, MERGE-ID Track, Rebecca Silver, Anne L. McCabe
| asm.org
Molecular Pathogenesis Michelle K. Paczosa, Rebecca J. Silver, Anne L. McCabe, Albert K. Tai, Colin H. McLeish, David W. Lazinski, Joan Mecsas Andreas J. Bäumler, Editor DOI: 10.1128/IAI.00034-20 ABSTRACT Klebsiella pneumoniae is a Gram-negative bacterial pathogen that causes a range of infections, including pneumonias, urinary tract infections, and septicemia, in otherwise healthy and immunocompromised patients. K.
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Amino Acid Biosynthetic Pathways Are Required for Klebsiella pneumoniae Growth in Immunocompromised Lungs and Are Druggable Targets during Infection

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By Rebecca Silver, Anne L. McCabe, MERGE-ID Track, Michelle K. Paczosa
| asm.org
Experimental Therapeutics Rebecca J. Silver, Michelle K. Paczosa, Anne L. McCabe, Joan-Miquel Balada-Llasat, James D. Baleja, Joan Mecsas DOI: 10.1128/AAC.02674-18 ABSTRACT The emergence of multidrug-resistant Klebsiella pneumoniae has rendered a large array of infections difficult to treat. In a high-throughput genetic screen of factors required for K. pneumoniae survival in the lung, amino acid biosynthesis genes were critical for infection in both immunosuppressed and wild-type (WT) mice.
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