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Meriam Shabbar on Muck Rack

Meriam Shabbar

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Nedd4-2 ablation in kidney improves glycaemic control in diabetic mice - Cell Death & Disease

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By Jantina Manning, Stuart Pitson, Meriam Shabbar
| Nature Verified
Abstract NEDD4-2, a ubiquitin ligase, regulates a number of ion channels and transporters by promoting their ubiquitination, internalisation and degradation, thereby affecting many signalling and physiological outcomes. Loss of this gene in mice results in tubular cell death and a chronic kidney disease (CKD)-like phenotype due to aberrant Na+ transport, caused by elevated expression of NEDD4-2 substrates including the epithelial sodium channel (ENaC).
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