Merida Rodriguez-Lopez

Eligibility criteria and losses to follow-up of at-risk women PE is generally diagnosed after 20 weeks of GA. However, there are rare PE cases diagnosed before 20 weeks, mostly associated with molar pregnancy, triploid or antiphospholipid syndrome. Recently, some PE cases have been identified even in the absence of such pathologies [38]. A high BP value <20 weeks is most likely diagnosed as CH [39].

In everyday clinical practice the definition of high risk women varies across guidelines. In some of them[ 5 , 6 ] the same definition is used interchangeably for further screening tests and for prescription of LDA. However, we demonstrate that the predictive accuracy of this current practice falls to reach the standard cutoff for acceptable discrimination[ 7 ]. For example, in the whole population, primiparity vs multiparity is currently considered as a moderate risk-factor.