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Metabolic Crosstalk

As seen in: Wiley Online Library, British Pharmacological Society
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Articles

Experimental Insights and Recommendations for Successfully Performing Cerebral Microdialysis With Hydrophobic Drug Candidates

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By Julia Sundheimer, Julia Benzel, Rémi Longuespée, Metabolic Crosstalk
| Wiley Online Library Verified
What is the current knowledge on the topic? ○ Cerebral microdialysis has been successfully applied to various drugs. However, hydrophobic compounds, which have a greater likelihood of crossing the BBB, pose unique challenges due to their propensity for non-specific binding. A comprehensive overview addressing these challenges is currently lacking. What question did this study address?
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Therapeutic drug monitoring of osimertinib in non‐small cell lung cancer and short bowel syndrome: A case report

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By Rémi Longuespée, Metabolic Crosstalk, Julia A. Kunz, Margaux Fresnais
| British Pharmacological Society
1 INTRODUCTION Cancer metastases in the digestive tract can greatly hamper its function. Ileus is one grave complication, which often necessitates enterectomy of affected segments in order to restore patency and preserve some bowel function from the remaining peristaltic loops without peritoneal carcinosis.
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