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Metabolic DiseasesI

As seen in: Frontiers
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Articles

Exploring epigenetic drift and rare epivariations in amyotrophic lateral sclerosis by epigenome-wide association study

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By Marta Nice, Ana Duarte, Metabolic DiseasesI, Danilo B. Medinas
| Frontiers
Introduction Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disorder that affects upper and/or lower motor neurons in the brain and spinal cord, leading to progressive muscle paralysis and death within 2–3 years after the onset. ALS is mainly sporadic (sALS; 90%) with a multifactorial etiology, while familial (fALS) forms are characterized by high genetic heterogeneity.
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