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Methinee Artami on Muck Rack

Methinee Artami

As seen in: Nature, BioRxiv
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Articles

Skin androgens regulate Staphylococcus aureus pathogenicity via quorum sensing - Nature Microbiology Original

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By Maria John, Mahendran Chinnappan, Camille I. Sturges, Methinee Artami, Mohini Bhattacharya, Rebecca Keogh, Jeffrey S. Kavanaugh, shivani jain, Hanna Y. Gedamu, Mauricio Velasquez, Mauricio Velásquez, Tripti Sharma, Jeffrey McDonald, Alexander R. Horswill, Tamia Harris-Tryon, Jessica Komarovsky
| Nature Verified
Abstract Skin cells secrete testosterone, with greater amounts secreted at the skin surface of males compared with females. Males are also more susceptible to skin infections than females. Here we report that mice engineered with testosterone-deficient skin are resistant to methicillin-resistant Staphylococcus aureus infections. Testosterone promoted the expression of S.
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Androgens at the skin surface regulate S. aureus pathogenesis through the activation of agr quorum sensing

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By Maria John, Mohini Bhattacharya, Mahendran Chinnappan, Methinee Artami
| BioRxiv
Abstract Staphylococcus aureus, the most frequent cause of skin infections, is more common in men than women and selectively colonizes the skin during inflammation. Yet, the specific cues that drive infection in these settings remain unclear. Here we show that the host androgens testosterone and dihydrotestosterone promote S. aureus pathogenesis and skin infection. Without the secretion of these hormones, skin infection in vivo is limited. Testosterone activates S.
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