Metti K. Gari

Abstract Recent epidemiological studies suggest that breast density and obesity together increase breast cancer risk. Although these risk factors have been explored individually, little is known about how they combine to alter the tumor immune microenvironment (TIME) and promote disease progression. To address this gap, we developed a murine model of both risk factors.

Abstract Purpose: Effective therapies for solid tumors, including breast cancers, are hindered by several roadblocks that can be largely attributed to the fibrotic extracellular matrix (ECM). Fibronectin (FN) is a highly upregulated ECM component in the fibrotic tumor stroma and is associated with poor patient prognosis. This study aimed to investigate the therapeutic potential of an anti-fibrotic peptide that specifically targets FN and blocks the fibrillar assembly of FN.

Dynamic Aqueous Transformations of Lithium Cobalt Oxide Nanoparticle Induce Distinct Oxidative Stress Responses of B. subtilis Lithium cobalt oxide (LiCoO2), an example of nanoscale transition metal oxide and a widely commercialized cathode material in lithium ion batteries, has been shown to induce oxidative stress and generate intracellular reactive oxygen species (ROS) in model organisms.