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Miaoge Xue

As seen in: Nature, Journal of Virology
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Articles

Vesicular Stomatitis Virus and DNA Vaccines Expressing Zika Virus Nonstructural Protein 1 Induce Substantial but Not Sterilizing Protection against Zika Virus Infection

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By Anzhong Li, Miaoge Xue, Zayed Attia, Jingyou Yu
| Journal of Virology Verified
Vaccines and Antiviral Agents Anzhong Li, Miaoge Xue, Zayed Attia, Jingyou Yu, Mijia Lu, Chao Shan, Xueya Liang, Thomas Z. Gao, Pei-Yong Shi, Mark E. Peeples, Prosper N. Boyaka, Shan-Lu Liu, Jianrong Li Adolfo García-Sastre, Editor DOI: 10.1128/JVI.00048-20 ABSTRACT The nonstructural protein 1 (NS1) of several flaviviruses, including West Nile, dengue, and yellow fever viruses, is capable of inducing variable degrees of protection against flavivirus infection in animal models.
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Vesicular stomatitis virus and DNA vaccines expressing Zika virus nonstructural protein 1 (NS1) induce substantial but not sterilizing protection against Zika virus infection

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By Miaoge Xue, Zayed Attia, Jingyou Yu, Anzhong Li
| Journal of Virology Verified
Vaccines and Antiviral Agents Anzhong Li, Miaoge Xue, Zayed Attia, Jingyou Yu, Mijia Lu, Chao Shan, Xueya Liang, Thomas Z. Gao, Pei-Yong Shi, Mark E. Peeples, Prosper N. Boyaka, Shan-Lu Liu, Jianrong Li DOI: 10.1128/JVI.00048-20 ABSTRACT The nonstructural protein 1 (NS1) of several flaviviruses, including West Nile, dengue, and yellow fever viruses, is capable of inducing variable degrees of protection against flavivirus infection in animal models.
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Viral N6-methyladenosine upregulates replication and pathogenesis of human respiratory syncytial virus

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By Zijie Zhang, Chuan He, Jiyong Zhou, Miaoge Xue
| Nature Verified
Abstract N6-methyladenosine (m6A) is the most prevalent internal modification of mRNAs in most eukaryotes. Here we show that RNAs of human respiratory syncytial virus (RSV) are modified by m6A within discreet regions and that these modifications enhance viral replication and pathogenesis. Knockdown of m6A methyltransferases decreases RSV replication and gene expression whereas knockdown of m6A demethylases has the opposite effect. The G gene transcript contains the most m6A modifications.
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