Miaohan Jin

Dear Editor, In mice, it has been reported that co-culturing naïve embryonic stem cells (ESCs) with trophoblast cells can give rise to embryonic-like structures in vitro that closely resemble E3.5 blastocysts at both the morphological and transcriptional levels1,2. More recent research has focused on generating embryo models by combining two or three different cell types through the overexpression of specific transcription factors.