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Miaolei Chen

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Articles

TRIM21-mediated OGT degradation inhibits breast cancer tumorigenesis and metastasis

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By Ao Zhang, Fei Tang, Jiawen Zhou, Qi Wang, Miao Zhao, Jiuling Zhu, Ziyang Yuan, Zhe Sun, Qianqian Shi, Lei Wu, Guodong Chen, Yuxin Shu, Xintian Chen, Shu Xiang Li, Zhongwei Li, Miaolei Chen
| Nature Verified
Abstract A variety of studies have indicated that the E3 ubiquitin ligase tripartite motif-containing 21 (TRIM21) plays a crucial role in the development and progression of various tumors. However, the specific functional mechanisms of TRIM21 in breast cancer, particularly in triple-negative breast cancer (TNBC), remain unclear. This study revealed that TRIM21 expression is reduced in breast cancer tissues and decreased in TNBC patients.
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