Michał Barbasiewicz

Functionalization of the pyridine ring plays a critical role in the synthesis of pharmaceuticals, pesticides, ligands, functional materials, etc., and remains an emerging field of synthetic methodology.

Sulfonyl compounds find countless applications in organic synthesis, medicinal chemistry, and material science, spanning from the sulfur fluoride exchange (SuFEx) reaction, Julia olefination, and Oppolzer sultam, to saccharin sweetener, ‘sulfa drugs’, and sulfourea herbicides, to name just a few. (1) Presence of the sulfonyl group affects bioproperties of the molecules, acting as a moderately lipophilic (2) electron acceptor and mimicking tetrahedral intermediates of acyl substitution reactions.

Buy Article Permissions and Reprints All articles of this category Heteroatom-based olefinating reagents (e.g., organic phosphonates, sulfonates, etc.) are used to transform carbonyl compounds into alkenes, and their mechanism of action involves aldol-type addition, cyclization, and fragmentation of four-membered ring intermediates.