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Michael Barravecchia on Muck Rack

Michael Barravecchia

As seen in: Nature, MDPI
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Articles

A gene therapy approach to prevent dilated intercellular space, a hallmark of gastroesophageal reflux disease

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By Jing Huang, Michael Barravecchia, Karen L. de Mesy Bentley, Jennifer Young, Zhongren Zhou, David Dean, Gillian M. Schiralli Lester, Lananh N. Whigham, Jada M. Hooker
| Nature Verified
Abstract The incidence of esophageal disease ranging from gastroesophageal reflux disease (GERD) to cancer has dramatically risen over the last 10 years. However, there have been limited descriptions of effective gene delivery methods for the esophagus. We developed a simple and effective electroporation-based gene delivery procedure to target the distal esophagus in living animals.
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Occludin Is Essential to Maintain Normal Alveolar Barrier Integrity and Its Protective Role During ARDS Progression

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By Xin Lin, Haiqing Bai, Michael Barravecchia, Rosemary Norman
| MDPI
All articles published by MDPI are made immediately available worldwide under an open access license. No special permission is required to reuse all or part of the article published by MDPI, including figures and tables. For articles published under an open access Creative Common CC BY license, any part of the article may be reused without permission provided that the original article is clearly cited. For more information, please refer to https://www.mdpi.com/openaccess.
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Caveolin-1 gene therapy inhibits inflammasome activation to protect from bleomycin-induced pulmonary fibrosis

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By Xin Lin, Michael Barravecchia, R. Matthew Kottmann, Patricia Sime
| Nature Verified
Abstract Idiopathic pulmonary fibrosis (IPF) is a devastating and fatal disease and characterized by increased deposition of extracellular matrix proteins and scar formation in the lung, resulting from alveolar epithelial damage and accumulation of inflammatory cells.
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