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Michael Brehler

As seen in: BioRxiv, Cell Press
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Articles by Michael Brehler

Autoantibody-triggered podocyte membrane budding drives autoimmune kidney disease

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By Karen Lahme, Wiebke Sachs, Sarah Froembling, Desiree Loreth, Vincent Böttcher-Dierks, Katrin Neumann, Frederik-Michael Hann, Nick Arkan, Michael Brehler, Julia Reichelt, Antonia Sgries, Kristin Surmann, Simone Gaffling, Marie R Adler, Pablo Saez, Uta Wedekind, Elena Tasika, Paul Saftig, Christian Conze, Roland Thünauer, Sinah Skuza, Stephanie Zielinski, Johannes Brand, Stefan Bonn, Stephan Michalik Verified, Uwe Völker, Marina Zimmermann, Thorsten Wiech, Catherine Meyer-Schwesinger, Alina Lampert, Karen Neitzel, Lars Fester, Tobias Meyer-Zedler
| Cell Press Verified
Keywords THSD7A PLA2R1 membranous nephropathy podocyte extracellular vesicle autoantibody clearance foot process effacement ADAM10 14-3-3 Introduction The incidence in kidney disease is increasing, evolving to a health crisis,1 and measures are urgently needed to prevent, identify, and treat the underlying causes. Injuries of the kidney blood-urine filter (glomerulus) are among the most frequent causes of chronic kidney disease.
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Podocyte exopher-formation as a novel pathomechanism in membranous nephropathy

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By Karen Lahme, Wiebke Sachs, Sarah Froembling, Michael Brehler
| BioRxiv
Abstract Background: Membranous nephropathy (MN) is caused by autoantibody binding to podocyte foot process antigens such as THSD7A and PLA2R1. The mechanisms of the glomerular antigen/autoantibody deposition and clearance are unknown. Methods: We explore the origin and significance of glomerular accumulations in (1) diagnostic and follow-up biospecimens from THSD7A+ and PLA2R1+-MN patients compared to nephrotic non-MN patients, and (2) in experimental models of THSD7A+-MN.
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