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Articles by Michael Briese
PARENTS FAMILIES
Catholic Clerical Sex Abuse I am a Roman Catholic priest. I have never been married. I have no children. My lifelong sense of family comes from the world and the vast numbers of all sorts of peoples I have been privileged to meet, serve, know and with whom I have lived. In America and with decades of powerful Church leadership involving homosexual Cardinals and bishops, thousands of boys and girls have been sexually assaulted and raped by thousands of Catholic priests.
Plekhg5 controls the unconventional secretion of Sod1 by presynaptic secretory autophagy - Nature Communications
Abstract Increasing evidence suggests an essential function for autophagy in unconventional protein secretion (UPS). However, despite its relevance for the secretion of aggregate-prone proteins, the mechanisms of secretory autophagy in neurons have remained elusive. Here we show that the lower motoneuron disease-associated guanine exchange factor Plekhg5 drives the UPS of Sod1.
hnRNP R promotes O-GlcNAcylation of eIF4G and facilitates axonal protein synthesis - Nature Communications
Abstract Motoneurons critically depend on precise spatial and temporal control of translation for axon growth and the establishment and maintenance of neuromuscular connections. While defects in local translation have been implicated in the pathogenesis of motoneuron disorders, little is known about the mechanisms regulating axonal protein synthesis.
Fr. Michael Briese: Silence is Complicity
Former U.S. Nuncio Viganò to Undergo Church Trial for Schism, Rejecting Pope Francis, by AC Wimmer LifeSiteNews: Archbishop Cordileone to offer Traditional Latin Mass during National Eucharistic Congress By Fr. Michael Briese, Substack, (Complicit Clergy), June 20, 2024 Another unfolding sexual abuse crisis is ongoing here in the Archdiocese of Washington.
Prevention of tau accumulation through inhibition of hnRNP R-dependent axonal Mapt mRNA localization
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Cytosolic Ptbp2 modulates axon growth in motoneurons through axonal localization and translation of Hnrnpr - Nature Communications
Abstract The neuronal RNA-binding protein Ptbp2 regulates neuronal differentiation by modulating alternative splicing programs in the nucleus. Such programs contribute to axonogenesis by adjusting the levels of protein isoforms involved in axon growth and branching. While its functions in alternative splicing have been described in detail, cytosolic roles of Ptbp2 for axon growth have remained elusive.
Vascular and neural transcriptomics reveal stage-dependent pathways to inflammation and cognitive dysfunction in a rat model of hypertension
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Publisher Correction: A systems view of spliceosomal assembly and branchpoints with iCLIP
Correction to: Nature Structural & Molecular Biology https://doi.org/10.1038/s41594-019-0300-4, published online 30 September 2019. In the supplementary information originally posted for this article, the Supplementary Information PDF file did not contain the Supplementary Figs. or Tables; it contained only a title page with the authors’ names and affiliations. The error has been corrected online.
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