Articles by Michael Fleming
Dual-photosensitizer polylactic acid filaments for 3D-printed photodynamic antimicrobial materials
CONFLICT OF INTEREST STATEMENT The authors declare no conflict of interest. DATA AVAILABILITY STATEMENT The data that support the findings of this study are available from the corresponding author upon reasonable request. Supporting Information Filename Description php70156-sup-0001-Figures.docxWord 2007 document , 545.4 KB Figure S1. Photographs of PLA specimens and sample holder used for optical characterization. Figure S2.
Why we must invest to sustain Delaware life science firms | Opinion
Michael Fleming, Special to the USA TODAY Network I first met Irene Rombel just months after joining Delaware Bio in the COVID summer of 2020. At the time she was an executive with Spark Therapeutics, the pioneering gene therapy company. As a strong believer in Delaware's life science ecosystem, Rombel saw value in Spark joining Delaware Bio and she made that happen.
Why we must invest to sustain Delaware life science firms | Opinion
I first met Irene Rombel just months after joining Delaware Bio in the COVID summer of 2020. At the time she was an executive with Spark Therapeutics, the pioneering gene therapy company. As a strong believer in Delaware’s life science ecosystem, Rombel saw value in Spark joining Delaware Bio and she made that happen. Soon after, she set out to build something new: a company using AI to transform how life-changing cell and gene therapies are manufactured.
The Physical Health Trajectories of Young People with Neurodevelopmental Conditions: A Protocol for a Systematic Review of Longitudinal Studies.
The authors have declared no competing interest. https://www.crd.york.ac.uk/prospero/display_record.php?ID=CRD42024516684 This work was supported by the Wellcome Trust [223499/Z/21/Z]. I confirm all relevant ethical guidelines have been followed, and any necessary IRB and/or ethics committee approvals have been obtained.
A Population-Based Cross-Sectional Investigation of COVID-19 Hospitalizations and Mortality Among Autistic People
Abstract Background: Current evidence suggests the possibility that autistic people may be at more risk of COVID-19 infection, hospitalisation, and mortality than the general population. Previous studies, however, are either limited in scale or do not investigate potential risk factors. Whilst many risk factors have been speculated to be responsible for severe COVID-19, this research has focused on general population samples.
Delaware sits at the center of life science leadership. We should capitalize on that more Original
Earlier this fall, two area researchers were awarded the Nobel Prize for their pioneering discoveries in mRNA. The “groundbreaking findings” of these University of Pennsylvania scientists, Katalin Karikó and Drew Weissman, were instrumental in the development of mRNA vaccines against COVID-19. It is remarkable to consider such world-altering efforts took place in our backyard — and perhaps even more striking that it took a Nobel Prize for most people to learn of it.
Pain and itch coding mechanisms of polymodal sensory neurons
Highlights • Polymodal MrgprD+ primary afferent neurons express Vglut2 and Nmb • Glutamate is required for both pain and itch signaling from MrgprD+ neurons • NMB is selectively required for itch signaling • NMBR+ central neurons are required for MrgprD+-neuron-mediated itch signals Summary Pain and itch coding mechanisms in polymodal sensory neurons remain elusive. MrgprD+ neurons represent a major polymodal population and mediate both mechanical pain and nonhistaminergic itch.
Slashing American IP rights will needlessly hurt Delaware's biotech sector | Opinion
3 minute read Michael Fleming Special to the USA TODAY Network U.S. Attorney General Merrick Garland recently announced arrests and charges associated with multiple schemes tied to the Chinese government's "relentless campaign to gain access to our technology." This multi-year effort is all too well understood by American researchers, who have been subjected to an unrelenting wave of foreign-inspired attempts to in the labs and billions of dollars in invested capital.
COVID-19 infection and outcomes in a population-based cohort of 17 203 adults with intellectual disabilities compared with the general population
Patient characteristics Of the 269 771 people (24 264 with, and 245 507 without, intellectual disabilities) included in our Census 2011 cohort, 255 916 (94.9%) were linked to the NRS Population Spine. The linkage rate was 92.9% (n=22 538) among people with intellectual disabilities and 95.1% (n=233 378) of the original 5% comparison sample with no intellectual disabilities or autism.
COVID-19 infection and outcomes in a population-based cohort of 17 203 adults with intellectual disabilities compared with the general population
COVID-19 infection and outcomes in a population-based cohort of 17 203 adults with intellectual disabilities compared with the general population Free http://orcid.org/0000-0002-6146-3477Angela Henderson1, Michael Fleming1, Sally-Ann Cooper1, Jill P Pell1, Craig Melville1, Daniel F Mackay1, Chris Hatton2, Deborah Kinnear1 1Institute of Health and Wellbeing, University of Glasgow, Glasgow, UK 2Department of Social Care and Social Work, Manchester Metropolitan University, Manchester, UK...
COVID-19 infection and outcomes in a population-based cohort of 17 203 adults with intellectual disabilities compared with the general population
COVID-19 infection and outcomes in a population-based cohort of 17 203 adults with intellectual disabilities compared with the general population Free http://orcid.org/0000-0002-6146-3477Angela Henderson1, Michael Fleming1, Sally-Ann Cooper1, Jill P Pell1, Craig Melville1, Daniel F Mackay1, Chris Hatton2, Deborah Kinnear1 1Institute of Health and Wellbeing, University of Glasgow, Glasgow, UK 2Department of Social Care and Social Work, Manchester Metropolitan University, Manchester, UK...
Educational and health outcomes of schoolchildren in local authority care in Scotland: A retrospective record linkage study
Loading metrics Open Access Peer-reviewed Research Article Michael Fleming , James S. McLay, David Clark, Albert King, Daniel F. Mackay, Helen Minnis, Jill P. Pell Michael Fleming, James S. McLay, David Clark, Albert King, Daniel F. Mackay, Helen Minnis, Jill P. Pell Published: November 12, 2021 https://doi.org/10.1371/journal.pmed.1003832 Figures Abstract Background Looked after children are defined as children who are in the care of their local authority.
American biomedical innovation is leading the world: Why would we stifle that? | Opinion
President Joe Biden was spot on when he recently told Congress that continued investment in research and development is essential to our country’s global leadership and economic security. Fortunately, the American bioscience sector is a shining exemplar of our nation’s unparalleled ability to nurture and produce engines of innovation that both benefit humankind and drive extraordinary economic opportunity at home through just that kind of sustained investment.
Using graphic modelling to identify modifiable mediators of the association between area-based deprivation at birth and offspring unemployment
Loading metrics Open Access Peer-reviewed Research Article James Bogie , Michael Fleming , Breda Cullen , Daniel Mackay , Jill P. Pell James Bogie, Michael Fleming, Breda Cullen, Daniel Mackay, Jill P. Pell Published: March 31, 2021 https://doi.org/10.1371/journal.pone.0249258 Figures Abstract Background Deprivation can perpetuate across generations; however, the causative pathways are not well understood.
COVID-19 vaccine underscores life-saving value of bioscience innovation
As the COVID-19 vaccine begins to be rolled out with our front-line healthcare workers and those most at risk in Delaware and across the country, it is worth reflecting on the historic nature of this extraordinary, life-saving achievement. Biopharmaceutical industry researchers have delivered one of the most impressive accomplishments in modern science: two safe, effective vaccines against a global plague, developed in record time.
Neurodevelopmental multimorbidity and educational outcomes of Scottish schoolchildren: A population-based record linkage cohort study
Loading metrics Open Access Peer-reviewed Research Article Michael Fleming , Ehsan E. Salim, Daniel F. Mackay, Angela Henderson, Deborah Kinnear, David Clark, Albert King, James S. McLay, Sally-Ann Cooper, Jill P. Pell Michael Fleming, Ehsan E. Salim, Daniel F. Mackay, Angela Henderson, Deborah Kinnear, David Clark, Albert King, James S. McLay, Sally-Ann Cooper, Jill P.
Mortality in 787,666 school pupils with and without autism: A cohort study
Introduction People with autism are at additional risk of mental and physical health conditions (Croen et al., 2015; Rydzewska et al., 2018a, 2018b; Simonoff et al., 2008), so may be at risk of earlier mortality than other people. A recent large Danish study of children and adults with autism reported a mortality hazard ratio of 2.0 (95% CI = 1.5–2.8) or 2.6 (95% CI = 2.0–3.3) for those born 1980–1995, and 1.3 (95% CI = 0.6–2.9) for those born 1996–2010 (Schendel et al., 2016).
Rates and causes of mortality among children and young people with and without intellectual disabilities in Scotland: a record linkage cohort study of 796 190 school children
Rates and causes of mortality among children and young people with and without intellectual disabilities in Scotland: a record linkage cohort study of 796 190 school children Abstract Objectives To investigate mortality rates and causes in children and young people with intellectual disabilities. Design Retrospective cohort; individual record linkage between Scotland’s annual pupil census and National Records of Scotland death register. Setting General community.
Transforming global health supply chains through data visibility
The COVID-19 pandemic has demonstrated how important supply chains are to health systems. The pandemic has also revealed the inherent cracks and lack of data visibility in healthcare supply chains in emerging countries. Without transparency, a health system cannot function properly, leaving people who receive its services vulnerable and without access to potentially lifesaving medicine. In many countries, supply-chain inefficiency is a matter of life and death.
Transforming global health supply chains through data visibility
Prior to 2018, Nigeria’s health supply chain was fraught with challenges. Data quality was poor, no central database meant no aggregate visibility, and data collection alone (which was manual and paper-based) cost between $3 million and $4 million a year. Before moving forward in the digitization journey, leaders decided to address the drawbacks of existing processes and capabilities—that is, a lack of technical skills and unified processes to manage data.
Daycare Injuries and Negligence According to Texas State Law
Daycare injuries can and do happen by accident, and in some cases, there may be no negligence or case against the facility. When parents drop their children off at a daycare, the daycare has a legal responsibility to care for the child and assumes the role of caregiver. Proper care is a requirement, that if breached, allows for parents of injured children to sue the daycare for negligence.
Educational and health outcomes of children treated for asthma: Scotland-wide record linkage study of 683 716 children
Introduction Asthma is the most common chronic disease of childhood in developed countries [1], affecting 1.1 million children in the UK [2]. Global prevalence is approximately 11% and 14% in children aged 6–7 and 13–14 years, respectively [1], and is increasing due to urbanisation of developing countries leading to environment and lifestyle changes [3]. Prevalence between countries [1, 4] varies from 2% to 20% among school-aged children through differing case ascertainment [5–13].
Educational and Health Outcomes of Children Treated for Type 1 Diabetes: Scotland-Wide Record Linkage Study of 766,047 Children
Epidemiology/Health Services Research Abstract OBJECTIVE This study was conducted to determine the association between childhood type 1 diabetes and educational and health outcomes.
Educational and health outcomes of children treated for asthma: Scotland-wide record linkage study of 683,716 children
Michael Fleming, Catherine A. Fitton, Markus F.C. Steiner, James S. McLay, David Clark, Albert King, Daniel F. Mackay, Jill P. Pell European Respiratory Journal 2019; DOI: 10.1183/13993003.02309-2018 Abstract Background: The global prevalence of childhood asthma is increasing. The condition impacts physical and psychosocial morbidity; therefore wide-ranging effects on health and education outcomes are plausible.
Denzel Washington's 2002 Playboy Interview Is a Still-Relevant Exploration of Race in Hollywood
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Near Failure of Long-Term Capital Management
On September 23, 1998, a group of fourteen banks and brokerage firms invested $3.6 billion in Long-Term Capital Management L.P. (LTCM) to prevent the firm’s imminent collapse. The capital infusion forestalled a fire sale of LTCM assets into already turbulent markets and instead allowed for an orderly liquidation of the hedge fund’s holdings. While the Federal Reserve brought the market participants together and oversaw the refinancing, it did not put its own funds at risk.
Dealer Trading and Positioning in Floating Rate Notes
In January 2014, the U.S. Treasury Department made its first sale of floating rate notes (FRNs), securities whose coupon rates vary over time depending on the course of short-term rates. Now that a few years have passed, we have enough data to analyze dealer trading and positioning in FRNs. In this post, we assess the level of trading and positioning, concentration across issues, and auction cycle effects, comparing these properties to those of other types of Treasury securities.
Lawyers and happiness: be led by the evidence
Lawyers are not, by the nature of their profession, the people most likely to be suffused with the warmth of human happiness. Their job often requires them to scan for problems for the potential breach of contract, the regulatory non-compliance; the hole in the argument, And then charge clients a lot of money to fend off their problems. Contributor Michael Fleming Head of KWC Legal – Kissing With Confidence. It can infuse their thinking with pessimism.
Market liquidity after the financial crisis
Market liquidity after the financial crisis The potential adverse effects of regulation on market liquidity in the post-crisis period continue to receive significant attention. This column shows that dealer balance sheets have continued to stagnate and that various measures point to less abundant funding liquidity. Nonetheless, there is little evidence of a wide-spread deterioration in market liquidity. Liquidity remained resilient even during stress events like the 2013 ‘temper tantrum’.
Educational and Health Outcomes of Children Treated for Attention-Deficit/Hyperactivity Disorder
Question Do schoolchildren treated for attention-deficit/hyperactivity disorder have worse education and health outcomes than their peers? Findings In this population-based cohort study, 766?244 singleton children attended Scottish schools between 2009 and 2013.
Left-lane laggards are getting in Delaware's way
I log a lot of highway miles each year, which provides ample time to contemplate life and the world’s many mysteries.
Zbigniew Brzezinski: The man who picked a pope
Zbig Brzezinski died the other night after an eventful and productive 89 years. Brzezinski was the hawkish national security adviser to President Jimmy Carter, a hard-line Cold Warrior whose ideology -- and crew cut – cast him as an outlier in a liberal 1970s post-Watergate administration that made human rights a centerpiece of its foreign policy. Outside of that four-year stint as a “senior White House official” (he knew how to work the press), Brzezinski spent his career as an academic.
Market Liquidity after the Financial Crisis
Market Liquidity after the Financial Crisis This paper examines market liquidity in the post-crisis era, in light of concerns that regulatory changes might have reduced dealers’ ability and willingness to make markets. We begin with a discussion of the broader trading environment, including an overview of regulations and their potential effects on dealer balance sheets and market making, but also considering additional drivers of market liquidity.
Evidence-Based Care: Ensuring the Right Thing for Every Patient, Every Time
There’s no such thing as a “typical patient," and for doctors, any tool that helps deliver better insights into a patient’s condition is a welcome one. At the same time, patients rely on doctors to treat them as individuals when seeking medical care. The advent of predictive and now prescriptive analytics elevates evidence-based care, which allows doctors to maximize positive, customized outcomes for their patients while maintaining a high standard of care.
Market Liquidity after the Financial Crisis
Market Liquidity after the Financial Crisis This paper examines market liquidity in the post-crisis era, in light of concerns that regulatory changes might have reduced banks’ ability and willingness to make markets. We begin with a discussion of the broader trading environment, including a discussion of regulations and their potential effect on dealer balance sheets and market making, but also considering plausible alternative drivers of market liquidity.
Use of Enhanced Body Mass Index Charts During the Pediatric Health Supervision Visit Increases Physician Recognition of Overweight Patients
The American Academy of Pediatrics recommends counseling about obesity-specific topics and measuring body mass index (BMI) at all health supervision visits. The authors compared the rates of overweight diagnosis and physician counseling at 2 clinics, one using color-coded BMI charts. The authors interviewed patients and reviewed their charts for differences in diagnosis and counseling rates.
Fleming: Is this hello or goodbye for Delaware?
Pay-day loan outfits have popped up along the Concord Pike and Kirkwood Highway and other unlikely locales in Newark, Bear, Claymont, Harrington and Milford. Delaware ranks 46th in the U.S. State Crime index. Property values for once solidly middle class neighborhoods across New Castle County are soft; you dont have to look too hard to find once tidy, prosperous blue-collar 1960s subdivisions looking a bit down on their heels, repairs put off, lawns unattended.
Order Flow Segmentation and the Role of Dark Trading in the Price Discovery of U.S. Treasury Securities
This paper studies the workup protocol, a unique trading feature in the U.S. Treasury securities market that resembles a mechanism for discovering dark liquidity. We quantify its role in the price formation process in a model of the dynamics of price and segmented order flow induced by the protocol. We find that the dark liquidity pool generally contains less information than its transparent counterpart, but that its role is not trivial.
Bringing Back the House Call
Years ago, as a family physician in Louisiana, I made house calls. Certain patients were too sick or too hurt to get to my office. Sometimes a condition or injury had worsened, requiring my evaluation bedside. I would visit patients at home for the simplest of reasons: home was where they needed care. By the mid-1980s, the pressures of time and money prevented most physicians from making house calls anymore. But I kept seeing patients at home until I retired from my practice after 29 years.
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