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Cytopathology and Prognostic Accuracy of 15-GEP/PRAME: The Collaborative Ocular Oncology Group Study 2 Key Points Question Is confirmatory cytopathology associated with the prognostic accuracy of a 15-gene expression profile (15-GEP)/Preferentially Expressed Antigen in Melanoma (PRAME) classifier in predicting metastatic uveal melanoma risk?
Results Color Fundus Photography The subcommittee agreed with the SUN 9,11. classification criteria that PIC lesions were smaller and located in the posterior pole. In contrast, MFCPU lesions were larger and could be identified in the posterior pole, nasal peripapillary retina, and in the periphery (Figures 1 and 2). MFC and PIC are characterized by multifocal lesions which appear creamy and ill-defined when active.
Correspondence: Yasmin S. Bradfield, MD, Department of Ophthalmology and Visual Sciences, University of Wisconsin–Madison, 2870 University Avenue, Suite 206, Madison, WI 53705. Email: ysbradfield@wisc.edu From the Department of Ophthalmology and Visual Sciences, University of Wisconsin–Madison, Madison, Wisconsin (KFE, YSB, MMA); and the University of Wisconsin–Madison School of Medicine and Public Health, Madison, Wisconsin (SMF).
Question Is there a significant difference in visual acuity with long-term follow-up of treatment with intravitreous fluocinolone acetonide implant or systemic anti-inflammatory therapy for severe intermediate, posterior, or panuveitis?
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