Michael Oh
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Articles by Michael Oh
A CCL21 gene-modified dendritic cell vaccine combined with pembrolizumab in advanced non-small cell lung cancer: a phase I trial
Abstract Immune checkpoint inhibitors (ICIs) have transformed treatment for non-small cell lung cancer (NSCLC), but resistance to these therapies is common. We report here results from a phase I trial combining intratumoral injection of a CCL21-expressing dendritic cell (CCL21-DC) vaccine with pembrolizumab in patients with advanced non-small cell lung cancer (ClinicalTrials.gov identifier: NCT03546361).
A (beautifully) imperfect gathering of a (beautifully) imperfect family hosted by a (beautifully) imperfect movement
‘When’s the Fifth Lausanne Congress?’ To be perfectly honest my heart drops a bit when I hear this very common question! After a nearly five-year journey that led to the Fourth Lausanne Congress in Seoul-Incheon, South Korea, I am not quite ready to think about tackling another incredibly joyful but incredibly weighty challenge! But I am also incredibly thankful that so many are asking and wanting another Lausanne Congress.
Tumor Heterogeneity and the Immune Response in Non-Small Cell Lung Cancer: Emerging Insights and Implications for Immunotherapy
All articles published by MDPI are made immediately available worldwide under an open access license. No special permission is required to reuse all or part of the article published by MDPI, including figures and tables. For articles published under an open access Creative Common CC BY license, any part of the article may be reused without permission provided that the original article is clearly cited. For more information, please refer to https://www.mdpi.com/openaccess.
JCM | Free Full-Text | Comparison of the Efficacy of Zoledronate and Denosumab in Patients with Acute Osteoporotic Vertebral Compression Fractures: A Randomized Controlled Trial
All articles published by MDPI are made immediately available worldwide under an open access license. No special permission is required to reuse all or part of the article published by MDPI, including figures and tables. For articles published under an open access Creative Common CC BY license, any part of the article may be reused without permission provided that the original article is clearly cited. For more information, please refer to https://www.mdpi.com/openaccess.
Outcome of Percutaneous Endoscopic Lumbar Discectomy in Relation to the Surgeon’s Experience: Propensity Score Matching
All articles published by MDPI are made immediately available worldwide under an open access license. No special permission is required to reuse all or part of the article published by MDPI, including figures and tables. For articles published under an open access Creative Common CC BY license, any part of the article may be reused without permission provided that the original article is clearly cited. For more information, please refer to https://www.mdpi.com/openaccess.
CXCL9/10-engineered dendritic cells promote T cell activation and enhance immune checkpoint blockade for lung cancer
Highlights • Intratumoral (IT) CXCL9/10-DC inhibits tumor growth in NSCLC murine models • IT CXCL9/10-DC induces T cell infiltration and activation inside the tumor • IT CXCL9/10-DC enhances the antitumor efficacy of immune checkpoint blockade • IT CXCL9/10-DC and anti-PD-1 combination leads to tumor-specific immune memory Summary Immune checkpoint blockade (ICB) with PD-1/PD-L1 inhibition has revolutionized the treatment of non-small cell lung cancer (NSCLC).
Dendritic Cell Vaccination in Non-Small Cell Lung Cancer: Remodeling the Tumor Immune Microenvironment
This is an early access version, the complete PDF, HTML, and XML versions will be available soon.
Microorganisms | Free Full-Text | Transient SARS-CoV-2 RNA-Dependent RNA Polymerase Mutations after Remdesivir Treatment for Chronic COVID-19 in Two Transplant Recipients: Case Report and Intra-Host Viral Genomic Investigation
1. Introduction In the community setting, people with chronic underlying conditions, including obesity, hypertension, diabetes mellitus, cardiovascular diseases, and respiratory disorders, are at a higher risk for developing severe COVID-19 []. In immunocompromised populations, SARS-CoV-2 infection is associated with prolonged viral shedding, more severe diseases, and generally worse outcomes [].
Love is Hard
Throughout my whole life, I had only been in one other relationship, a short-lived, adolescent-fueled fling that lasted a few months in middle school. It might have continued longer if not for my family deciding to move, but that's neither here nor there. So for the majority of my adult life, I've been single. I was never a fan of dating culture. Going out to places for the sole purpose of finding someone was not my idea of fun.
How Languages Change Your Thoughts
As a native English speaker, I tend to see the world through a series of processes. First one thing occurs, then another, and another, and so forth. This is how most English sentences are typically structured. The subject does an action on an object. Through this rather straightforward way of forming sentences, we can often predict how sentences are going to end.
The Joy of Getting Lost
You know the saying, "It's about the journey, not the destination." As an avid traveler sometimes I find that true, other times I don't. But during one of my day trips from Osaka, that saying became gospel. It was a wonderfully warm day for January and my goal for the day was to visit the Suntory Yamazaki Distillery. I hopped on the train heading from Osaka to Kyoto and got off at Yamazaki.
Lonely Travel
In January of this past year, I took a solo trip to Japan. A trip 3 years in the making thanks to COVID. My original plan was to go with a few of my closest friends, but one by one they dropped out and I was left to go on this trip alone. I was excited. Sure, my friends wouldn't be with me, but I would finally get to experience the trip of a lifetime. Me, alone with my basic Japanese conversational skills. The flight was certainly pleasant.
Lessons I Learned From Travel
We are creatures of comfort. We grasp the familiar tight and loath letting it go. Even if you go through the same routine day in and day out, at least it's comfortable, at least it's safe. There is nothing wrong with living like this. Nothing wrong with wanting to be comfortable. I know many people like this who are content with their lives. You may be one of those people. Mired with the familiar. Swaddled in the blanket of comfort. I find that blanket too stifling.
Asia: The Early Innings of Innovation?
I think one of the better ways to invest for the long-term is to latch onto trends in a region and, in Asia, one of the long-term trends that we see is innovation. We believe focusing on innovation is a better approach to finding growth companies in this region. I'd like to explain how we think about innovation. Most people associate innovation with breakthrough products, but we’ve broadened that concept to include companies that are implementing new ideas to build great businesses in Asia.
Uncapped Innovation
How do you view the current state of innovation within Asia? A lot of the focus from international investors has been on innovative tech stocks in China. It’s not surprising. Since the initial public offering (IPO) of Ant Group was cancelled in 2020, the Chinese government has overhauled regulation of its booming internet and e-commerce sectors.
Choosing The Best Multi-Currency Wallet For Crypto in 2020
By CoinJoy on The Capital Crypto differs from fiat in terms of storage. It is saved not in some kind of virtual bank, but directly in the blockchain. The coins, information on the distribution of digital assets between users, transaction history — all this data is stored by the chain. Such data cannot be changed or erased in any way. And without a crypto wallet, you cannot manage your assets.
Early assessment of molecular progression and response by whole-genome circulating tumor DNA in advanced solid tumors
Research Article Andrew A. Davis, Wade T. Iams, David Chan, Michael S Oh, Robert W. Lentz, Neil Peterman, Alex Robertson, Abhik Shah, Rohith Srivas, Timothy J Wilson, Nicole J. Lambert, Peter S. George, Becky Wong, Haleigh W. Wood, Jason C. Close, Ayse Tezcan, Ken Nesmith, Haluk Tezcan and Young Kwang Chae DOI: 10.1158/1535-7163.MCT-19-1060 Abstract Treatment response assessment for patients with advanced solid tumors is complex and existing methods require greater precision.
Nous, le un pour cent des chrétiens, présentons nos excuses aux quatre-vingt-dix-neuf autres pour cent de chrétiens
Assis en face d'un ami, Bill Pollard, je voyais son regard empreint d'un espoir qui cependant trahissait quelques doutes. Je venais de partager avec lui la vision du Mouvement de Lausanne de réunir plus de 700 leaders chrétiens du monde des affaires, venant de plus de 100 pays un peu partout dans le monde.
African and West Indian Christians Are Changing the UK Church
The number of churches continues to drop in the UK. As CT reported last month, there are only 39,000 congregations left in the country, a quarter drop from 20 years ago. But despite churches increasingly closing their doors and the number of people attending church falling, this bad news isn’t across the board. For Black Majority Churches, the numbers actually look a lot healthier.
Um Pedido de Perdão do 1% de Cristãos aos Outros 99%
“Mas eles escutarão?" Eu sentei à mesa voltado ao meu amigo Bill Pollard, que estava com uma expressão facial esperançosa e levemente duvidosa. Eu acabara de compartilhar com ele sobre a visão do Movimento de Lausanne de reunirmos mais de 700 cristãos, líderes em seu local de trabalho, de mais de 100 países. Bill amou a visão: mobilizar os cristãos no local de trabalho para serem instrumentos de Deus para levarem o impacto do reino para cada esfera da sociedade.
Una Disculpa al 99% de los Cristianos de Parte del 1%
“¿Pero escucharán?” Estaba sentado mesa por medio con un amigo, Bill Pollard, cuyo rostro tenía una expresión de esperanza y cierta duda. Acababa de compartirle la visión del Movimiento de Lausana de convocar a más de 700 líderes cristianos de más de 100 países que pertenecen al ámbito laboral. A Bill le encantó la visión: movilizar a cristianos del ámbito laboral como instrumentos de Dios para llevar el impacto del reino a todas las esferas de la sociedad.
An Apology to the Christian 99%, from the 1%
But will they listen?” I sat across the table from a friend, Bill Pollard, who had a hopeful but slightly doubtful look on his face. I had just shared with him the Lausanne Movement’s vision to convene more than 700 Christian workplace leaders from more than 100 nations. Bill loved the vision: to mobilize Christians in the workplace as God’s instruments to bring kingdom impact in every sphere of society.
The Christian Backstory of Hong Kong’s Pro-Democracy Protests
In April, nine Hong Kong activists were convicted for participating in the pro-democracy Occupy Central and Umbrella Movement protests. One of those was a Baptist pastor, Chu Yiu-Ming. In the courtroom, he painted a vivid picture of the faith that had transformed his life and inspired his activism: “We have no regrets. We hold no grudges, no anger, no grievances. We do not give up,” he said, speaking on behalf of fellow activists striving to bring universal voting rights to Hong Kong.
We Set Off to Reach a Remote Tribe in the Amazon. Turns Out, They Were Waiting for Us.
Editor’s Note: Last year, John Allen Chau’s fatal mission to India’s North Sentinel Island, home to the world’s most isolated tribe, spurred new conversations about Christians making first contact with indigenous people.
Detection of Minimal Residual Disease Using ctDNA in Lung Cancer: Current Evidence and Future Directions
To view the full text, please login as a subscribed user or purchase a subscription. Click here to view the full text on ScienceDirect. Figure 1 Proposed design for clinical trial evaluating tailored treatment based on circulating tumor DNA–based detection of minimal residual disease (MRD). Abstract Advances in DNA sequencing methods have significantly expanded the potential clinical applications of analyzing circulating tumor DNA (ctDNA).
Why Christians Should Care about Nelson Mandela, Justice, and Gospel Proclamation
Editor's note: Michael Oh, executive director/CEO of the Lausanne Movement, was a member of the official delegation of Christian leaders at today's memorial service for Nelson Mandela in South Africa. Spontaneous shouts of "Tata Madiba!" in chorus of voice and body spread like waves throughout the stadium long before Nelson Mandela's memorial service even began today in South Africa. I turned to the Archbishop of Johannesburg to ask what they were saying.
New Chapter for Korea Peninsula After U.S.-North Korea Summit
President Trump and North Korea's leader Kim Jong Un held a long-anticipated summit meeting that marks a potential turning point for the Korean peninsula and the region at large. In this Q&A, Portfolio Manager Michael Oh discusses the longer term implications for investors. What positive outcomes do you see from the recent U.S./North Korea summit? The summit was an important step toward greater understanding and cooperation on the Korean peninsula.
2017 Science Writing Contest Winners
We received more than 200 entries for our science writing contest, but we have three standout pieces that are all being published in print issues of Christianity Today, as well as a few finalists that will be published online. The entrants wowed us: from beautiful writing on songbirds and fish eyeballs to haunting pieces on viruses, lyme disease, and aging. And we learned a few things, too. We learned about mirror neurons, lunar soil, and absolute zero.
Molecular Biomarkers of Primary and Acquired Resistance to T‐Cell‐Mediated Immunotherapy in Cancer: Landscape, Clinical Implications, and Future Directions
The emergence of immunotherapy has revolutionized cancer treatment in recent years. Inhibitors of immune checkpoints, including antibodies against cytotoxic T‐lymphocyte‐associated protein 4, programmed cell death protein 1, and programmed death ligand 1, have demonstrated notable efficacy in certain advanced cancers.
Signs of Spiritual Awakening in Japan
Japan is known by many to be a difficult mission field. But for those who know missions in Japan well, the phrase “hard mission field” is merely a euphemism for a grimmer expression that was previously used about Africa, one that has been recently applied to Japan: “the missionary’s graveyard.” One would expect such a bleak designation to be used in reference to a land known for physical hardship or violent persecution, and there have been martyrs in Japan’s Christian history.
Why Investors Should Tune Into K-Pop Culture
Most investors have long been familiar with South Korea’s major brands, including those for automobiles and semiconductors that are exported all across the globe. These multinationals—the first wave of the country’s export-oriented companies—have propelled South Korea’s growth since the 1960s. They typically manufacture products that require hefty capital expenditure.
Missions as Fasting
I'm not Japanese. I'm Korean. And there is a history of horrible treatment of the Koreans by the Japanese. People ask me, "Why Japan, then? Why would a Korean person chose to do missions in Japan?" It's because Jesus said, "Love your enemies." If you look beyond the high technology and smiles, they are a nation that is desperately lost. They are spiritually, sexually, and socially lost. The Japanese need the Lord and our love as well.
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