Michael Paul Cancro on Muck Rack

Michael Paul Cancro

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Articles

Spatial atlas of diabetic kidney disease reveals a B cell-rich subgroup

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By Bernhard Dumoulin, Jonathan Levinsohn, Konstantin A. Klötzer, Chenyu Li, Liran Mao, Eunji Ha, Samer Mohandes, Thao Nguyen Verified, Thảo Nguyen, Luca Paruzzo, Daigoro Hirohama, Victoria Fang, Vijay G. Bhoj, Hamideh Parhiz, Magaiver Andrade-Silva, Amin Abedini, Andi Bergeson, Daniel Traum, Michael MaY, Michael May, Klaus H. Kaestner, Marco Ruella, Fiona McAllister, A. Ari Hakimi, Mingyao Li, Matthew Palmer, E. John Wherry, Christopher Hunter, Katalin Susztak, Michael Paul Cancro
| Nature Verified
Abstract Diabetic kidney disease (DKD), the leading cause of kidney failure, is marked by clinical and molecular heterogeneity, making therapeutic development exceedingly difficult1. Here we used Xenium and CosMx single-cell spatial transcriptomics, integrated with single-nucleus RNA sequencing, to build a cross-platform kidney atlas that makes tissue architecture computable for prognosis, non-invasive detection and patient selection.
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