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Michael Raymond

As seen in: Nature, Patch, Science Magazine, Lexology, Mondaq, Bluffton Today, Sports Agent Blog, Food and Drink Business
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Articles

Evolution of botulinum neurotoxin serotype X proteases to induce inflammatory cell death in cancer cells

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By Julia McCreary, Colin Hemez, Michael Raymond, Travis R. Blum, Angel Gonzalez-Valero, Teresa L. Augustin, Nicholas A. Krasnow, Stephan DeCarlo, Yan Qin, Kaitlin Rhee, Wei Jiang, Blanche Ip, Ahmad Khalil, David R. Liu
| Nature Verified
Abstract Triggering protease-activated cell death is a promising strategy for cancer treatment. Here, we used phage-assisted evolution to reprogram botulinum neurotoxin serotype X proteases to cleave and activate procaspase-1 and gasdermin D, key effectors of inflammatory cell death. We also developed an efficient system to broadly characterize the substrate specificity of wild-type and evolved botulinum neurotoxin serotype X protease variants.
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All Change For UK AIFMD? Simpler But Not Always Easier…

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By Tim Lewis, Phil Bartram, Michael Raymond
| Mondaq
Tim Lewis’s articles from Travers Smith LLP are most popular: with readers working within the Banking & Credit industries What is the UK AIFMD review? HM Treasury and the Financial Conduct Authority (FCA) have published the much-awaited proposals on changes to the UK AIFMD regime. The changes aim at simplifying and clarifying the UK AIFMD regime and removing some of the less effective rules as part of the general growth and competitiveness objective.
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SFDR 2.0 – Council Of The EU Negotiating Position: Broadly Welcome Changes, But Will They Survive Trilogue?

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By Tim Lewis, Phil Bartram, Michael Raymond
| Mondaq
Tim Lewis’s articles from Travers Smith LLP are most popular: with readers working within the Aerospace & Defence, Technology and Construction & Engineering industries In November 2025, the European Commission published its legislative proposal to update the EU Sustainable Finance Disclosure Regulation (dubbed "SFDR 2.0"), which was preceded a week before by a leaked draft version that was widely discussed in the media.
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