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Michael T. Bardo on Muck Rack

Michael T. Bardo

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Behavioral and transcriptomic markers of susceptibility to escalate fentanyl intake

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By Richard Charnigo, Emily Prantzalos, Mengfan Xia, Emily D. Denehy, Justin Miller, Pavel I. Ortinski, Jill Turner, Jack Keady, Jakob D. Shaykin, Cody Bumgardner, Michael T. Bardo
| Nature Verified
Abstract The “loss of control” over drug consumption, known as escalation of intake in opioid use disorder (OUD), is well-established in preclinical rodent models. However, little is known about how antecedent behavioral characteristics, such as valuation of hedonic reinforcers prior to drug use, influence fentanyl intake trajectories. Moreover, it is unclear if distinct escalation phenotypes are driven by transcriptomic markers predictive of OUD susceptibility.
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