Michael Thomas Clandinin on Muck Rack

Michael Thomas Clandinin

As seen in: MDPI
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Articles

Interorgan Metabolism of Ganglioside Is Altered in Type 2 Diabetes

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By Michelle Beveridge, Michaelann Wilke, Edmond A. Ryan, Michael Thomas Clandinin
| MDPI
Abstract : GM3 is implicated in cell signaling, inflammation and insulin resistance. The intestinal mucosa metabolizes ganglioside and provides gangliosides for uptake by peripheral tissues. Gangliosides downregulate acute and chronic inflammatory signals. It is likely that transport of intestinal derived gangliosides to other tissues impact the same signals characteristic of inflammatory change in other chronic conditions such as Type 2 Diabetes (T2DM).
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