Michael Tymianski

ABBREVIATIONS: AC1 agreement coefficient 1CC/IT intercaudate distance-to-inner-table widthESCAPE-NA1 Safety and Efficacy of Nerinetide (NA-1) in Subjects Undergoing Endovascular Thrombectomy for StrokeGCA global cortical atrophyh-ICD hemi-intercaudate distanceMTA medial temporal atrophy Brain atrophy is considered an important imaging surrogate of brain reserve, the ability of the brain to cope with acquired tissue injuries, such as stroke, demyelination, or trauma.1⇓⇓⇓⇓⇓-7 There is...

The goal of any clinical trial is to operationalize a paradigm in which the study enrolls the greatest proportion of responders in a setting that maximizes that study intervention’s treatment effect. Such a trial would have the most power to detect the therapeutic benefit it seeks to evaluate. Importantly, the trial should be grounded in—and consistent with—the pre-clinical science of the test intervention.

Background and Purpose—Basilar trunk aneurysms (BTAs), defined as aneurysms distal to the basilar origin and proximal to the origin of the superior cerebellar artery, are rare and challenging to manage. We describe the natural history and management in a consecutive series of BTAs. Methods—Between 2000 and 2013, 2522 patients with 3238 aneurysms were referred to our institution for aneurysm management.