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Michaelyn C. Lux on Muck Rack

Michaelyn C. Lux

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Articles

Structural basis for transthiolation intermediates in the ubiquitin pathway - Nature

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By Tomasz Kochańczyk, Zachary S. Hann, Michaelyn C. Lux, Derek Tan
| Nature Verified
Abstract Transthiolation (also known as transthioesterification) reactions are used in the biosynthesis of acetyl coenzyme A, fatty acids and polyketides, and for post-translational modification by ubiquitin (Ub) and ubiquitin-like (Ubl) proteins1,2,3. For the Ub pathway, E1 enzymes catalyse transthiolation from an E1~Ub thioester to an E2~Ub thioester.
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Design and Semisynthesis of Biselectrophile-Functionalized Ubiquitin Probes To Investigate Transthioesterification Reactions

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By Michaelyn C. Lux, Cheng Ji, Zachary S. Hann, Tomasz Kochańczyk
| dx.doi.org
Download Hi-Res ImageDownload to MS-PowerPointCite This:Org. Lett. 2024, XXXX, XXX Avelyn Mae V. Delos Reyes Chemical Biology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, New York 10065, United States Pharmacology Program, Weill Cornell Graduate School of Medical Sciences, Memorial Sloan Kettering Cancer Center, New York, New York 10065, United States , Michaelyn C.
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Photomediated ring contraction of saturated heterocycles

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By Justin Jurczyk, Michaelyn C. Lux, Donovon A. Adpressa, Sojung Kim
| Science Magazine Verified
Research Article View ORCID ProfileJustin Jurczyk1,†, View ORCID ProfileMichaelyn C. Lux2,†, View ORCID ProfileDonovon Adpressa3, View ORCID ProfileSojung F. Kim1, View ORCID ProfileYu-hong Lam4,*, View ORCID ProfileCharles S. Yeung2,*, View ORCID ProfileRichmond Sarpong1,* 1Department of Chemistry, University of California, Berkeley, CA 94720, USA. 2Discovery Chemistry, Merck & Co., Inc., Boston, MA 02115, USA. 3Analytical Research and Development, Merck & Co. Inc., Boston, MA 02115, USA.
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